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KMID : 0360419750110010027
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Korean Journal of Pharmacology
1975 Volume.11 No. 1 p.27 ~ p.31
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A Comparison of the Responses of Lower Vertebrate Intestines to Prostaglandin E₁ and E₂
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Hong Ki-Whan
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Abstract
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1. The isolated strips of guinea-pig, fowl and reptiles (snake and tortoise) showed consistenly excitatory responses to PGE₁ and E₂, which were dose-dependent.
2. Frog intestine revealed inhibitory responses to both PGE₁ and PGE₂ except a small of PGE₂ (1-10 ng/ml) caused slight contraction.
3. The intestines of pieces showed inconsistent responses to PGE₁ and E₂ In fresh-water fish(carp), PGE₁ produced relaxation under the dose of 50 ng/ml, and contraction by the large doses, but PGE₂ consistently caused contraction in dose-dependent manner. However, the strips of sea-water fish rovealed the different responses to PGE compound: PGE₁ caused relaxation and PGE₂ conversly contraction even though in small degree.
4. These results that there are genera differences in the responses of the longitudinal strips of intestine to PGE₁ and PGE₂ was assumed to be possibly correlated with evolutionally primitive function of gut.
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KEYWORD
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